Obesity is an public health problem leading to other metabolic diseases and its prevalance globally increasing. A disturpt in molecular regulation of appetite metabolism causes to obesity by leading to hyperphagy. Dietary pattern affects directly to appetite regulation. Therfore, dietary pattern is so important for obesity prevalance. There are many factor in appetite mechanism having complex system. One of these factors is endocannabinoid system. Over activation of endocannabinoid system relating to dietary fat pattern leads to obesity by increasing food intake. The aim of this research is to investigate effects of dietary fat pattern on obesity through endocannabinoid system.