Goat milk is recognized as an important dairy product due to its nutritional value and the presence of bioactive compounds that may contribute to human health. The composition and quality of goat milk are influenced by a wide range of factors that interact throughout the production process, leading to considerable variation in its physicochemical, nutritional, and microbiological properties. This review provides a comprehensive overview of the major determinants affecting goat milk composition and quality by integrating genetic, nutritional, physiological, and management-related perspectives. Genetic factors, including breed characteristics and gene polymorphisms associated with milk synthesis, play a significant role in determining milk yield and the concentrations of fat, protein, lactose, and fatty acids. Nutritional factors influence milk composition through dietary nutrient supply, forage quality, feeding strategies, and supplementation practices, which can alter the nutritional and functional properties of milk. Physiological factors such as age, parity, stage of lactation, health status, and endocrine regulation also contribute to variations in milk composition and production performance. In addition, management practices, including housing conditions, hygiene standards, animal welfare, and milking procedures, are essential for maintaining milk quality and safety. The available evidence suggests that goat milk quality is shaped by the complex interaction of genetic potential, nutritional inputs, physiological status, and management conditions. Understanding these interrelated factors is essential for improving milk quality, enhancing production efficiency, and supporting the sustainable development of dairy goat production systems. This review highlights the importance of integrated management strategies to maximize the nutritional and technological value of goat milk under diverse production environments.