ARCHIVES
VOL. 11, ISSUE 1 (2026)
Degenerative diseases associated with macronutrient imbalance and dietary intervention: A comprehensive review
Authors
Vishalakshi G Hanamanal, Uma Kulkarni
Abstract
Degenerative diseases represent a significant
and growing global public health challenge, characterized by the progressive
deterioration of cellular, tissue, and organ function. Although aging and
genetic predisposition are non-modifiable contributors, dietary
factors—particularly macronutrient intake—constitute a critical and modifiable
determinant of disease development and progression. Macronutrients, namely
carbohydrates, proteins, and fats, are fundamental to metabolic homeostasis,
energy provision, and structural maintenance. However, chronic excesses or
deficiencies in these nutrients disrupt metabolic regulation and promote
insulin resistance, oxidative stress, chronic inflammation, and mitochondrial
dysfunction, thereby accelerating degenerative processes. This comprehensive
review synthesizes current evidence on the physiological roles of
macronutrients and elucidates the mechanisms through which macronutrient
imbalance contributes to a wide spectrum of degenerative diseases, including
metabolic, cardiovascular, neurodegenerative, and musculoskeletal disorders. In
addition, the review presents extensive disease examples associated with
imbalances in individual macronutrients and evaluates evidence-based dietary
interventions aimed at restoring metabolic balance. By integrating
pathophysiological insights with practical nutritional strategies, this review
underscores the pivotal role of balanced macronutrient intake in the prevention
and management of degenerative diseases and highlights nutrition as a
cornerstone of healthy aging and chronic disease mitigation.
Download
Pages:69-74
How to cite this article:
Vishalakshi G Hanamanal, Uma Kulkarni "Degenerative diseases associated with macronutrient imbalance and dietary intervention: A comprehensive review". International Journal of Food Science and Nutrition, Vol 11, Issue 1, 2026, Pages 69-74
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.