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VOL. 10, ISSUE 4 (2025)
Bioactive compounds of Eurycoma Longifolia Jack and its potentials in pharmaceutical products and applications on The Global Market: A review
Authors
Phuc NT Le, Anh N Nguyen, An DX Nguyen, Nhi BP Nguyen, Phu H Le
Abstract
The aim of this study was to review the
bioactive compounds of Eurycoma longifolia and examine its
pharmacological effects, recent clinical applications, and commercial product
usage in the global market. E. longifolia, commonly known as Tongkat
Ali and belonging to the Simaroubaceae family, is a traditional medicinal
plant native to Southeast Asia, including Malaysia, Indonesia, Thailand, and
Vietnam, where it has been traditionally used to enhance vitality and treat a
variety of ailments. The methods used involved a comprehensive review of
current scientific literature and clinical trial data to identify the primary
bioactive constituents of E. longifolia, as well as an overview of its
pharmacological properties and commercial applications. The results showed that
the root of E. longifolia is rich in diverse bioactive compounds,
notably quassinoids (Eurycomanone, eurycomanol, and eurycomalactone),
flavonoids, saponins, polysaccharides, and alkaloids. These compounds
demonstrate multiple pharmacological activities, including hormonal regulation,
antimicrobial, antiparasitic, anti-malarial, anti-inflammatory, and
anti-diabetic effects. Recent clinical studies have provided evidence
supporting its role in testosterone enhancement, athletic performance
improvement, fertility support, and stress and metabolic syndrome management.
As a result, Tongkat Ali is increasingly used in dietary supplements,
functional foods, and global wellness products. The review contributes to a
deeper understanding of E. longifolia’s therapeutic potential and its
expanding role in modern health interventions. It highlights the scientific
basis for its traditional uses and underscores its relevance in contemporary
clinical and commercial contexts, offering insights for future research,
product development, and integrative medicine practices.
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Pages:56-62
How to cite this article:
Phuc NT Le, Anh N Nguyen, An DX Nguyen, Nhi BP Nguyen, Phu H Le "Bioactive compounds of <i>Eurycoma Longifolia</i> Jack and its potentials in pharmaceutical products and applications on The Global Market: A review". International Journal of Food Science and Nutrition, Vol 10, Issue 4, 2025, Pages 56-62
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