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VOL. 10, ISSUE 2 (2025)
Exploring the material basis and mechanism of action of galangal in improving functional constipation based on network pharmacology
Authors
Lijing Yan
Abstract
Research Objective Applying network pharmacology to explore the
material basis of galangal and its mechanism of improving constipation. Me thod
the effective components of galangal were collected, selected, and detected
through the pharmacology database and analysis platform (TCMSP), and the
corresponding target proteins were found in the "TCMSP" database.
Match the corresponding genes of target proteins in the "Uniprot" and "Swiss Target Prediction"
databases; The relevant results were visualized and analyzed for net work
topology using Cytoscape v3.9.0 software. Collect relevant targets related to
constipation diseases based on keywords such as "Constipation", "Intrinsic p eristalsis",
"Interstitial cells of Cajal", and "Intrinsic inflammation"
in databases such as "GeneCards" and "Drugbank"; Build a
Venn diagram using the "Table" database and create a bubble chart of
the enrichment results. Knowing the key targets of sorghum for improving
constipation, and importing them into the"STRING" database to obtain
the protein interaction network diagram of key proteins; Perform GO functional
and KEGG pathway enrichment analysis on key targets using the Metascape
database. Result Using the database,30 effective active ingredients and 138
target genes of galangal were obtained. There were 2248 target genes related to
constipation disease. After analysis,167 net work nodes and 515 edges were
identified, with an average node value of 5.56. Seven active ingredients were
screened, including quercetin, kaempferol, β -siIi tosterol, apigenin, emodin,
oleic acid, and galangin. Keep enrichment
analysis revealed 102 signaling pathways. Analysis has found that substances such
as quercetin, kaempferol, and β - sitosterol may be active ingredients in the laxative
and laxative properties of ginger. Conclusion Galangal may improve co nstipation
by regulating the calcium signaling pathway, phosphatidylinositol sign aling
pathway, PI3K Akt signaling pathway, and other pathways through active
ingredients such as quercetin, kaempferol, β - sitosterol,
apigenin, emodin, olei c acid, and galangal, as well as targets such as PTGS2, CHRM1,
CHRM3, and ADRB2.
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Pages:23-35
How to cite this article:
Lijing Yan "Exploring the material basis and mechanism of action of galangal in improving functional constipation based on network pharmacology". International Journal of Food Science and Nutrition, Vol 10, Issue 2, 2025, Pages 23-35
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