Scope: Consumption of fruits and vegetables has been inversely associated with morbidity and mortality from degenerative diseases. As different citrus compounds and fruit extracts provide a variety of physiological benefits and they are widely used in nutritional supplements and food products. However, there are no systematic studies comparing their efficacy at a cellular level. Methods and results: In this study, we evaluated the efficacy of select citrus fruit extracts and their active compounds for their antioxidant potential and protection against damage from oxidative stress in different types of human cells. Our results show the beneficial effects of different citrus compounds as well as whole fruit extracts in a quantitative and comparative manner. Using a variety of tests, we show citrus compounds and fruit extracts may work via different mechanisms. Conclusion: Our work demonstrates the beneficial effects of these phytochemicals and whole fruits at the cellular level.