One among India’s greatest human development challenges were malnutrition, which was India’s silent emergency. The malnutrition was real and its crisis had profound and frightening implications for children, society and the future human kind. Malnutrition affects children’s changes of survival, increases their susceptibility to illness, reduces their ability to learn and make them less productive later in life. This study was designed to determine the effect of formulated health mix powder on nutritional status of Preschool children. The study was carried out in Sholayoor tribal region. Total samples of 300 pre-school (3-5 years) children were selected randomly by purposive sampling method. Total number of 60 moderate acute malnourished (MAM) children was selected to participate in the intervention. The selected children were divided into two groups. The groups consisted of Control group (n=30) and Experimental group (n=30). The health mix powder was prepared in three variations. Based on the organoleptic evaluation, variation I was selected and considered for supplementation. This was used for shelf life study. From the shelf life study it was revealed that the formulated product could be used up to one month without any spoilage. The formulated health mix supplementation was provided to the experimental group, daily two times for a period of 90 days. The biochemical parameters like Serum total protein level, serum albumin and globulin level, blood haemoglobin level, clinical symptoms, anthropometric measurements and nutritional knowledge were assessed initial and finally. This study results concluded that the health mix powder increased the anthropometric and haematological parameters in the experimental group.