Oxidative and antioxidant stress markers in cirrhosis
Kalinca S Oliveira, Luana Reis, Nathaniele Barther, Gilson P Dorneles, Alessandra Peres, Sabrina A Fernandes, Gabriela P Coral
Chronic liver diseases are frequently associated with increased oxidative stress. The purpose of the study was to evaluate the correlation among oxidative and antioxidant stress markers with the cirrhosis etiology, food consumption and the liver disease severity. Transversal and prospective study, of patients with hepatitis C vírus (HCV) or alcoholic cirrhosis. There was a predominance of males in the alcoholic etiology group. The vitamin E consumption was associated with the MTT antioxidant increase. Levels of MTT, TBARS, NOX and AOPP were similar between the two etiologies. Increased AOPP levels were directly related to the liver disease severity in the HCV group. This study suggests an increase in oxidative stress according to the liver disease severity in HCV etiology. The increase of the MTT antioxidant in patients with higher intake of vitamin E suggests that food intake influences the amount of antioxidant in the plasma of patients with cirrhosis.