Canthium coromandelicum (Burm. f.) Alston leaves are widely used in ayurvedic medicine. Present study was conducted to quantify the proximate, mineral content and selected secondary phytochemicals which were present in Canthium coromandelicum (Burm. f.) Alston leaves. Dried leaves of Canthium coromandelicum (Burm. f.) Alston was used to analyse proximate composition, AAS analysis and qualitative as well as DPPH Scavenging activity was carried out to quantify the constituents. According to the results of the study, leaves contained alkaloids, flavonoids, saponins and polyphenolic compounds while total polyphenol content was observed as 17.27±0.19 mg/GAE/100g along with total alkaloid content, total saponin content and antioxidant content (IC₅₀ valve) were detected as 0.007±0.00mg/g, 0.10±0.01 mg/g and 10.88 mg/ml respectively. Percentage of moisture, carbohydrate, crude protein, crude fiber, ash content and crude fat content were accounted for 65.21±1.54%, 12.17%, 8.27±0.89%, 6.41±1.18%, 6.17±0.07% and 1.77±0.14% respectively. Canthium coromandelicum leaves contained 461.89mg/100g of Potassium, 348.47mg/100g of Calcium, 46.71mg/100g of Sodium and 10.19mg/100g of Fe. Based on the findings, Canthium coromandelicum (Burm. f.) Alston leaves have potential for fulfilling both dietary and medicinal requirement.