Effect of protein deficiency on teratogenicity obtained from the ethanolic extract of the seed of Garcinia kola
Tobi Olasope, Kolawole W Suliaman
The effect of a single subcutaneous dose of 25 mg kg-’ the ethanolic extract obtained from the seed of Garcinia kola given on day 6 of gestation were compared in weanling rats fed 5% protein for 3 weeks followed by normal protein diet (referred to as 5% normal protein diet) for the remainder of the experimental period (GROUP 1), rats maintained on 10% protein diet (GROUP 2), and rats on a normal protein diet throughout (GROUP 3). Administration of the Ethanolic extract obtained from the seed of Garcinia kolaresulted in significant depression of fetal body weights in rat fed 10%protein diet. Malformations (gross and skeletal) occurred in all the treated groups, Major gross malformations after treatment were hydrocephaly, microphthalmia and anophthalmia. The major skeletal defects involved vertebrae, sternebrae, and ribs the highest incidence of skeletal malformations occurred in treated rats maintained on 10% protein diet throughout the experiment.