Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) inhibit 1IL-β, Cox-2 and TNFα proinflammatory cytokines in an experimental liver obesity model of wistar rats
Michely L Nunes, Gabriela F Hahn, Vanessa T Bortoluzzi, Marilene G Porawski
The obesity is characterized by a state of inflammation of adipose tissue expansion, causing metabolic diseases. Objetive: to evaluate the effects of ômega-3 in the inflammatory process in liver tissue of rats on experimental obesity model induced by high-fat diet for 16 weeks. 40 Wistar rats were used, the animals were dividid in to 4 groups: control (CO), omega-3 control (CO+O), obese (O) and Obese plus omega-3 (O+O). Omega-3 has been administered at the dose of 1g/kg by gavage during the last 30 day of the diet. The omega-3 significantly reduced triglycerides and cholesterol of obese animals. As measured by TBARS, in SOD and CAT activity there was no difference between the groups.The activity of the GPx enzyme was significantly increased in the obese animals compared to the (CO+O) group and there was a reduction in the (Obese+O) group. The immunohistochemical labeling of TNFα, IL-1 and COX-2 was shown to be decreased in the hepatic tissue of animals (O+O) treated with omega-3 compared to obese and (CO) groups.. Conclusion: the results seem to indicate that the active compound omega-3 had na antioxidante and antiinflammatory in this model.