The effect of Cyperus esculentus (Tigernut) oil on liver, kidney and hematological biomarkers in low dose streptozocin and high fat diet exposed male wistar rats
Nwawuba Stanley U, Okechukwu Francis C
The purpose of this study is to investigate the effect of Cyperus esculentus (tiger nut) tuber oil on liver, kidney and hematological biomarkers in low dose Streptozocin (35mg/kg) and high fat diet exposed male wistar rats. Cyperus esculentus tuber oil was extracted from the tuber using a soxhlet extractor with n-hexane as solvent and the proximate and mineral analyses of high fat diet were done according to Standard procedure. A total of 40 rats between the weights of 88-115g were divided into five group’s n=8, and some selected groups were subsequently fed with a high fat diet for 30days and then intraperitoneal injected with 35mg/kg Streptozotocin. Analysis of liver, kidney function biomarkers (AST, ALT and ALP), (Creatinine, Urea, Sodium and Potassium) and hematological parameters (PCV, Hb, RBC and WBC) were conducted using standard procedures. The result findings showed that Cyperus esculentus oil significantly lowered p<0.05 levels of liver, kidney biomarkers and maintained the levels of hematological parameters. We concluded that Cyperus esculentus oil exhibited hepatoprotective ability, enhances renal function and maintains hematological status thus do not cause anemia and it is non-toxic.