This review article reviews the uses and effects of Monosodium Glutamate (MSG) on Food & Nutrition. various research articles, journals, conference papers were reviewed in recognizing the uses and effects of Monosodium Glutamate from 1908. Glutamate performs numberless essential roles in intermediary metabolism and is present in large quantities in the organs and tissues of the body. Even though much published studies are not being published on glutamate intake in relation to obesity or overweight in human, a study done in China provided anthropological data that glutamate intake may be related with increased risk of overweight irrespective of physical activity and total energy intake. Thus several studies again had proven using animals and humans, that glutamate did not increase food intake or induce obesity. MSG has also been described as a trigger for migraine headache exacerbations.