Milk thistle (Silymarin) and curcumin are the most famous medical plants which have attracted the attention of many investigators for long time. The present study aimed to evaluate the possible effects of a partial replacement of soybean meal in control economic diet by milk thistle and/ or curcumin on the possible harmful changes in improvement the liver and kidney functions and lipid profiles in male rats. Feeding diet supplemented with milk thistle and/ or curcumin increased the food intake, body weight rate and relative organ weights of kidney, heart and testes and decrease the liver and kidney functions and lipid profiles. The used of milk thistle alone or either mixture with curcumin are good supplements for growing without any adverse effect on the functions of liver, kidney and testis in rats.