Aloe Vera (Aloe barbadensis Miller) is one of the most widely used medicinal plants in traditional and modern medicine ^{[1, 2]}. The plant contains more than 200 biologically active compounds, including polysaccharides, anthraquinones, vitamins, minerals, enzymes, and amino acids ^[3-5]. These phytochemicals contribute to a wide range of pharmacological activities including antioxidant, anti-inflammatory, antimicrobial, wound healing, immunomodulatory, and metabolic regulatory effects ^[6-8].

Aloe Vera has extensive applications in nutraceuticals, pharmaceuticals, dermatology, and cosmetic formulations ^{[9, 11]}. Both oral and topical preparations of Aloe Vera have been investigated in clinical trials for conditions such as diabetes, wound healing, gastrointestinal disorders, and inflammatory skin diseases ^{[1, 12, 14]}. The primary bioactive compound, acemannan, plays a crucial role in immune modulation and tissue repair ^{[15, 17]}. This review summarizes the botany, cultivation, phytochemistry, pharmacological mechanisms, dermatological applications, and clinical evidence supporting the therapeutic use of Aloe Vera ^{[18, 19]}.