To verify the impact of the consumption of camu-camu, fruit native to the Amazon, with high content of ascorbic acid and phenolic compounds, in the treatment of Metabolic Syndrome (MS). A double-blind, documental, descriptive and analytical experimental study including 58 adult individuals overweight (BMI> 30) of both sexes. Two groups were formed: experimental (EG) (n=29) and control (CG) (n=29). The EG group received a capsule containing camu-camu, holding approximately 442 mg of vitamin C for 45 days, and CG received a capsule (placebo) for the same time period. Both groups received a balanced hypocaloric diet associated with regular physical activity and were followed up in individual consultations, inserting nutritional assessment data at the beginning and end of the study, as well as monthly anthropometric evaluations. The daily supplementation of camu-camu capsules in the diet associated with regular physical activity contributed to the improvement of the MS indicators. The research was registered at CEP under CAAE n. 32780814.7.0000.5020. There was a significant reduction in some indicators of MS diagnosis, such as: decreased blood pressure (p=0.012), triglycerides (p=0.011), abdominal circumference (p=0.038) and increased HDL-c (p=0.001), as well as the practice of physical activity (p=0.013). The daily supplementation of camu-camu capsules in the diet associated with regular physical activity contributed to the improvement of the MS indicators.