The purpose of the present work was to evaluate the proximate composition, minerals content (Na, K, Ca, Fe, Cu, Mn, Mg and Zn), simultaneous quantification of water soluble vitamins (like ascorbic acid, thiamine, riboflavin, niacin, pantothenic acid, pyridoxine and folic acid) by HPLC of five different Invasive Alien Species (IAS) viz. Alternanthera paronychioides, Cleome rutidosperma, Mikania micrantha, Pilea microphylla and Scoparia dulcis. The result showed the highest calorific value of C. rutidosperma (124.220 ± 0.581 kcal/100g) which was also found to contain highest amount of protein (15.802 ± 0.115%). An appreciable quantity of carbohydrate was estimated in the leaves of S. dulcis (13.906 ± 0.131%) and A. paronychioides (13.610 ± 0.215%). A. paronychioides had the highest potassium content (3.916 ± 0.003 mg/g) and calcium content (5.902 ± 0.005 mg/g). The sodium content ranged between 0.071 – 0.125 mg/g. The leaves of M. micrantha (152.253 ± 0.033 mg/100g) contained a very good amount of vitamin C. The water soluble B vitamin content in these plants under investigation ranged between 0.014 to 2.457 mg/100gm.The results indicate that these IAS can be utilized as feed supplement.