Elastin is restricted to few amino acids and its protein constitutes blood vessels in the body as well as tumors. It is believed that when the body is deprived of those amino acids that constitute elastin, little amount would be available to constitute those tumors. The study aims to obtain the score of amino acids that could theoretically supply minimum amino acids to build the protein elastin. This was achieved by compositing five underutilized legumes using Response Surface Methodology (RSM). The RSM revealed that there were strong interactions between the legumes in minimizing amino acids score. The optimized condition that gave a desirability of 1 was 15 % of Vigna subterranean, 10 % of Cajanus cajan, 20 % of Phaseolus lunatus, 21.50 % of Canavalia ensiformis and 33.50 % of Mucuna pruriens. The optimized legume composite gave an AASE value (8.25 %) closer to the predicted value of 8.60 %.