International Journal of Food Science and Nutrition

International Journal of Food Science and Nutrition


International Journal of Food Science and Nutrition
International Journal of Food Science and Nutrition
Vol. 5, Issue 1 (2020)

Comparative study on the health status of diabetic patient and non- diabetic people, age group of (40-55 years) after Intake garlic as a Probiotic


Sudip Kumar Das, DB Shinde, Tanushree Jana

Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Several pathogenic processes are involved in the development of diabetes. Garlic is one of the oldest cultivated plants all over the world, and is regarded as food as well as traditionally a medicine. Garlic extract is a compound of various biological activities, and proved to be beneficial for human bodies due to its antimicrobial, antioxidant, anticarcinogenic, antimutagenic, antiasthmatic, immunomodulatory, and prebiotic effects. Previous studies have already demonstrated that it can reduce the level of blood pressure and cardiovascular events in severe hypertensive patients. Also, it might play positive roles in the primary prevention of colorectal cancer and cardiovascular mortality, although the effects were not completely confirmed. Currently, garlic extract is becoming one of the most extensively studied drugs, and the positive effects of garlic supplements on blood glucose control and liquid regulation were further reported, which attracted more and more attention from researchers. A series of randomized controlled trials (RCTs) of high quality were designed to investigate its efficacy in the management of T2DM during last the decades. As a promising traditional food and medicine, together with its potential advantages of multiple targets, wide distribution, low cost, and rare complications, garlic would have a very important and significant influence on current clinical management of T2DM if its efficacy were confirmed. However, due to the limited sample size and verified outcomes, there is not yet a comprehensive and quantitative analysis with high reliability. Therefore, a meta-analysis through identifying all available RCTs was conducted to evaluate systematically the efficacy and safety of garlic supplements in the management of T2DM on blood glucose, as well as blood liquids including total cholesterol, triglyceride, high density lipoprotein (HDL), and low density lipoprotein (LDL) regulation
Pages : 75-81